Only CD14+HLA-DR−/low MDSCs from the paracancer liver tissue of CRLM patients significantly suppressed proliferation (35.58 ± 5.73% vs. 48.65 ± 5.03%, P < 0.05; Fig. 8c, d) and IFN-γ production (220.17 ± 39.69 pg/ml vs. 373.50 ± 46.53 pg/ml, P < 0.01; Fig. 8e) of autologous PBMCs compared to those of the hemangioma patients. The gene discussed is IFNG; the disease is hemangioma.