In the tumor cell lines of the activated B cell-like subtype of diffuse large B-cell lymphoma, inhibition of S1PR1 expression by shRNA in the lymphoma cells validated that blocking S1PR1 affects the expression of STAT3 and STAT3 downstream genes critically involved in tumor cell survival, proliferation, tumor invasion, and/or immunosuppression13. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.