The capacity of lungs endothelial cells to cross-present the malaria antigen at different time points of infection, strongly suggested that cross-presentation was the limiting factor for vascular leakage to occur, as despite the simultaneous presence of iRBC and specific-CD8+T cells in the lung tissue at 5 dpi, no significant difference in cross-presentation was observed compared to naive (Fig. 6). The gene discussed is CD8A; the disease is malaria.