It is precisely because this lack of mechanism and effective treatment in the VMC, based on our previous data, our present study devoted to illuminate the relationship between CPCs-Ex and the Akt/mTOR in CVB3-induced apoptosis, proving that CPCs-Ex could suppress the CVB3-induced apoptosis and replication in H9C2 cells and myocarditis rat model, which indicating that CPCs-Ex could be a novel and significant therapeutic strategy for VMC. The gene discussed is AKT1; the disease is myocarditis.