Hyperbaric oxygen decreased expression of IL-1β, increased the gene expression of aggrecan and type II collagen, suppressed the phosphorylation of p38 MAPK, decreased NO, PGE-2, and MMP-3, and increased TIMP-1 expression in nuclear pulposus cells lending support to the concept that IL-1β and the p38 MAPK signal play a significant role in the inflammatory and catabolic changes associated with disc degeneration and hyperbaric oxygen treatment may be of therapeutic benefit in this condition [24–26]. This evidence concerns the gene IL1B and intervertebral disk degenerative disorder.