In this context, the study by Shan et al. [6] is noteworthy which showed that hyperglycemia increased anulus fibrosis cell apoptosis in a JNK and p38 mitogen-activated protein kinase (MAPK) pathway dependent manner implying that efforts directed to inhibit this pathway may form a new approach to prevent disc degeneration. This evidence concerns the gene MAPK8 and Hyperglycemia.