This is supported by the observation that LXA4 is of significant benefit in a rat model of non-compressive lumbar disc herniation by inhibiting ERK, JNK and NF-kB/p65, and pro-inflammatory cytokines IL-1β and TNF-α, and up-regulating the expression of anti-inflammatory cytokines: TGF-β and IL-10 [30]; and 14, 15-EET (epoxyeicosatetraenoic acid, also derived from AA (Figure 7 for the metabolism of EETs) protected rat nucleus pulposus cells against death induced by TNF-α in vitro by inhibiting the NF-κB pathway and local administration of 14,15-EET prevented IVD degeneration [31]. This evidence concerns the gene NFKB1 and lumbar disc herniation.