Changes in the cytoskeleton and related phenotypic genes are often associated with the development of EMT in epithelial tumor cells, such as a decrease in the epithelial marker E-cadherin and the interstitial marker N-cadherin, an increase in Vimentin or other protein involved in tight junctions, loss of polarity and morphological changes of mesenchymal cells, which result in decreased adhesion of tumor cells and an enhanced exercise capacity [24]. This evidence concerns the gene CDH2 and neoplasm.