A total of 28 patients with newly diagnosed IDH1-mutated AML age 75 years or older or with comorbidities that precluded the use of intensive induction chemotherapy (e.g., ECOG performance status 2–3, severe cardiac or pulmonary disease, hepatic impairment with bilirubin > 1.5 × upper limit of normal, or creatinine clearance < 45 mL/min) were treated with ivosidenib for a median duration of 4.3 months (range 0.3–40.9) [61]. This evidence concerns the gene IDH1 and acute myeloid leukemia.