FLT3 and acute myeloid leukemia: Notably, the combination was effective in high-risk subgroups: ≥ 75 years, CR + CRi 65% and median duration of response 9.2 months (95% CI 6.4–12.4); adverse genetics (TP53, FLT3-ITD), CR + CRi 60%, median duration of response 6.7 (95% CI 4.1–9.4); and secondary AML, CR + CRi 67% with median duration of response not reached (95% CI 12.5-not reached).