However, aside from anthracycline approvals in the 1970s to 1990s and tretinoin’s approval for acute promyelocytic leukemia in 1995, no novel agents were approved for AML until 2000, when the FDA granted accelerated approval to gemtuzumab ozogamicin (GO) for older patients with relapsed CD33-positive AML. Here, CD33 is linked to acute myeloid leukemia.