There hub genes were IFITM1, RTP4, ACSF2, GSTM2, GSTM1, ACOX2, COL4A6, ITGA2, AKR1B1, NPY, CFTR, GPX7, ALDH3A1, CRYZ, ALDH2, MAOB, GSTP1, GPX3, XAF1, and BST2 (Fig. 8), which might play important roles in DNA methylation in prostate cancer patients. Here, GSTP1 is linked to prostate carcinoma.