A recent report from our group evaluating intratumoral delivery of checkpoint antibodies targeting CTLA-4, PD-1, and 4-1BB in combination with low-dose STING agonist in the TRAMP-C2 model of prostate cancer showed abscopal tumor regression with combination efficacy correlating with systemic antitumor immune responses [26]. The gene discussed is PDCD1; the disease is prostate cancer.