In preclinical models, by releasing high amounts of growth factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), pancreatic tumor cells activate an abnormal myelopoiesis that promotes the recruitment of a heterogeneous population of myeloid cells characterized by a strong immunosuppressive activity [6, 7]. This evidence concerns the gene CSF2 and pancreatic neoplasm.