Prominent uptake of PEI-GOS-PEG-FA-Rho was observed in the tumor, while relatively low signals were observed in other parts of the mouse body at 24 h p.i. Mice injected with PEI-GOS-PEG-Rho or free Rho solutions at the same concentrations showed relatively lower fluorescent signaling intensity. This evidence concerns the gene RHO and neoplasm.