In a Luminal/HER2-negative breast cancer model (i.e., MCF7), vinorelbine at 2 nM induced apparent G1-phase accumulation as well as the induction of CDK inhibitor p21(WAF1/CIP1) protein and the dephosphorylated form of retinoblastoma protein [16]. The gene discussed is CDKN1A; the disease is breast carcinoma.