The plasma DAO level (HR = 1.126, P < 0.001), the Child-pugh score (HR = 3.700, P < 0.05), GI bleeding (HR = 5.179, P < 0.001), HE (HR = 4.375, P < 0.001), SBP (HR = 3.077, P < 0.001) and HGB (HR = 0.979, P < 0.05) were the risk factors for the 6-month readmission of HBV-related decompensated cirrhosis. This evidence concerns the gene CYGB and hereditary elliptocytosis.