INS and Insulin resistance: Although, we hypothesize that high intake of iron may lead to increased risk of iron overload and then enhance the generation of inflammation, which can cause insulin resistance and then hyperinsulinaemia; these conditions may reduce insulin-mediated suppression of hormone-sensitive lipase (enzyme responsible for mobilization of triglyceride), which can increase intracellular lipolysis, plasma levels of free fatty acids and their transport to the liver.