Although, we hypothesize that high intake of iron may lead to increased risk of iron overload and then enhance the generation of inflammation, which can cause insulin resistance and then hyperinsulinaemia; these conditions may reduce insulin-mediated suppression of hormone-sensitive lipase (enzyme responsible for mobilization of triglyceride), which can increase intracellular lipolysis, plasma levels of free fatty acids and their transport to the liver. This evidence concerns the gene LIPE and Insulin resistance.