Consistent with the univariate analysis, a striking association for uc011aoc (APOBEC3A/B) with APOBEC-mutational signature was observed in breast cancer (P = 5.3 × 10− 11), and an additional association was also observed in lung adenocarcinoma (P = 0.01) (Table 1). The gene discussed is APOBEC3A; the disease is lung adenocarcinoma.