Although the statistical power varied across cancer types due to different sample sizes and different proportions of germline APOBEC3A/B deletion carriers, our result showed that the association of uc011aoc (APOBEC3A/B) with APOBEC-mutational signature observed in breast cancer was stood out, which was 1.6 ~ 5 times of the associations compared to other cancer types (Table 1). The gene discussed is APOBEC3A; the disease is breast cancer.