We conducted univariate analyses to evaluate associations of APOBEC-mutational signature with the overall gene expression levels of APOBEC3A and APOBEC3B. We observed that APOBEC3A expression level was positively associated with APOBEC-mutational signature in a total of six cancer types – bladder, breast, cervical, lung adenocarcinoma, head and neck, and thyroid. The gene discussed is APOBEC3A; the disease is cancer.