Using multiple regression analyses that included all isoforms of both APOBEC3A and APOBEC3B, we found that the expression levels of uc003awn (APOBEC3A) and uc003awo (APOBEC3B) were independently and commonly associated with evaluated APOBEC-mutational signature in multiple cancer types: bladder (a marginal association for uc003awn), breast, cervical, lung adenocarcinoma, and head and neck (Table 1). This evidence concerns the gene APOBEC3A and lung adenocarcinoma.