Using multiple regression analyses that included all isoforms of both APOBEC3A and APOBEC3B, we found that the expression levels of uc003awn (APOBEC3A) and uc003awo (APOBEC3B) were independently and commonly associated with evaluated APOBEC-mutational signature in multiple cancer types: bladder (a marginal association for uc003awn), breast, cervical, lung adenocarcinoma, and head and neck (Table 1). The gene discussed is APOBEC3B; the disease is lung adenocarcinoma.