SH2B1 and obesity due to melanocortin 4 receptor deficiency: The locus chr16:28719857 (p-value 4.36 × 10− 6) contains genes associated with body fat percentage (APOBR) [67] and BMI (SH2B1) [68], and rs12154393 (p-value 3.06 × 10–6) contains THSD7A, a candidate gene for obesity [58].