Thirdly, rs17606253 (p-value 1.85 × 10− 6) harbored TRAF3IP2, a protein implicated in mucosal immunity and IL-17 signaling, and associated with a trait involving high levels of A. actinomycetemcomitans and a profile of aggressive periodontal disease [107]. The gene discussed is TRAF3IP2; the disease is periodontal disorder.