The locus near rs2012033 was associated in both primary caries GWASs (dft p-value 8.21 × 10− 7; dfs p-value 1.40 × 10− 6) and harbored a candidate gene for hypodontia (CHST8) [129] and a gene associated with obesity and preference for carbohydrate (KCTD15) [130]. This evidence concerns the gene KCTD15 and tooth agenesis.