MTNR1B and obesity due to melanocortin 4 receptor deficiency: Other loci with connections to obesity and related disorders include chr13:96271864 (p-value 3.62 × 10− 6) that harbors the obesity-associated gene HS6ST3 [123], rs422342 (2.39 × 10− 6), which includes MAP 2 K5, also associated with BMI [125], and rs6483205 (p-value 1.24 × 10− 6) which contains MTNR1B, polymorphisms in which are associated with fasting glucose [134] and type 2 diabetes [135].