CXCL12 and cancer: Mushroom protein-bound glycan isolated from Polystictus Versicolor, PSK or Krestin, which are currently used as adjunctive therapies for various types of cancers in Japan, showed promising potential as anti-HIV agents by downregulating viral replication and promoting the upregulation of specific antiviral chemokines (RANTES, MIP-1α/β, and SDF-1α) known to block HIV-1 coreceptors in THP1 cells and human PBMCs [40].