SLC39A8 and schizophrenia: Zhang, et al. found that the ZIP8 Ala391-to-Thr391 substitution had an effect on intracellular cadmium accumulation and they suggested that pleiotropic effects of rs13107325, which is involved in multiple biological characters including schizophrenia, may attribute to cadmium-induced cell toxicity, highlighting the prominent effect of cadmium transmission [42].