Meanwhile, the circ-Foxo3 expression level (2.8 × 10− 5-5.761, median 0.1198) was also lower in de novo AML patients than in control people (1.2 × 10− 5-3.210, median 0.5017) (P = 0.04). The gene discussed is FOXO3; the disease is acute myeloid leukemia.