The expression of Foxo3 and circ-Foxo3 were positively corrected not only in cell lines (K562, U937, NB4, SHI-1, and HEL) (R = 0.98, P < 0.0021) (Fig. 3), but also in AML patients (R = 0.63, P < 0.0001) (Fig. 3). The gene discussed is FOXO3; the disease is acute myeloid leukemia.