The results showed that the potential signaling pathways such as Central carbon metabolism in cancer, Proteoglycans in cancer, GnRH signaling pathway, TNF signaling pathway, Focal adhesion, MAPK signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, Pyrimidine metabolism and Purine metabolism might be involved. This evidence concerns the gene AKT1 and cancer.