Links to various cardiovascular diseases are suggested by bioinformatics analysis and include heart failure, thoracic aortic aneurysm rupture, and subarachnoid hemorrhage.47 There is extensively described association of PIEZO2 mutations with joint contracture (arthrogryposis),87,88 but links to cardiovascular disease are also suggested in relation to heart failure, diastolic blood pressure, hypertensive heart disease, subarachnoid hemorrhage, varicose veins, and thoracic aortic aneurysm rupture.47 Further studies are warranted to explore the significance in human cardiovascular disease. This evidence concerns the gene PIEZO2 and thoracic aortic aneurysm.