PPIG and congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency: In addition, PORD affects a number of key CYP enzymes involved in hepatic function (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) that metabolize a large number of the xenobiotics and drugs that are used in clinical practice [218].