MYC and cancer: Moreover, the re-expression of wild-type PNRC1, but not of a mutant form unable to interact with the decapping complex and to promote U3 and U8 decapping, restrained the hyper-proliferation of cancer cell lines overexpressing either oncogenic RAS or C-MYC, thus suggesting that these oncogenes rely on functional U3 and U8 snoRNAs to sustain cancer progression.