In particular downregulation of glioma-associated tumor suppressor phosphatase and tensin homolog (PTEN) and Tet methylcytosine dioxygenase 3 (TET3) and upregulation of cancer-related genes such as SERTA domain-containing protein 1 (SERTAD1) and protein transport protein Sec61 subunit gamma (SEC61G) have been observed in NSC cells after treatment with exosomes isolated from GSC cells [94]. This evidence concerns the gene TET3 and central nervous system cancer.