IFNB1 and infection: However, studies by de Kort H et al. suggest that rapid lytic replication of BKV occurs in tubular epithelial cells, because these cells are immunologically tolerant to BKV infection rendering them more susceptible to high levels of lytic replication when compared to other glomerular cells that are more immunologically responsive to BKV infection, as demonstrated by a robust induction of interferon beta (IFNβ) and CXCL10 in the latter, post-infection [60].