DDAH1 and hyperhomocysteinemia: Taking into account that overexpression of DDAH1 protected from hyperhomocysteinemia-induced hypertrophic changes in the vessel wall, but not from impairment in the NO-mediated endothelial function in our study, it is possible that the observed effects of DDAH1 in the vascular wall were at least partially ADMA- and NO-independent [71].