HSP90B2P and neoplasm: In response to heat shock stress [68,202,205,206], intracellular accumulation of misfolded proteins [3,207,208,209,210,211,212], or tumor-promoting signaling such as phosphatidylinositol 3-kinases (PI3K)-Akt-mTOR signaling [200,213], HSF1 is activated and translocated into the nucleus, where it binds to HSP genes promoters and fosters their transcription.