Cytotoxic immune cells including NK cells, CTL, and natural killer T (NKT) cells can recognize HSP and HSP peptides expressed on the membrane surface of tumor cells and infected erythrocytes by the receptor CD94, also known as killer cell lectin-like receptor D1 (KLRD1) [10,11], stimulating cytotoxicity with induced release of granzyme B [10,97]. This evidence concerns the gene KLRD1 and neoplasm.