HSP90B2P and neoplasm: Therefore, ex-HSP, including mHSP, can activate malignancy events in tumor cells and, in contrast, can trigger antigen cross-presentation and cross-priming by APCs and stimulate the cytolytic immune cells such as natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTL) [34,35,36,37] (see Section 3 and Section 4).