Considering age, several genes responsible for inflammatory protein secretion/activation (KLK3, EDN3), cell-adhesion (PI4KA, AHSAI1) and cancer-related proteins (KLK3, FGFR1/2, PRKACA, and RAC2) were also modulated in AYA-RMS (Supplementary Table S4). This evidence concerns the gene PRKACA and cancer.