Gene Set Enrichment Analysis (GSEA) pathway analysis of RMS tumor samples revealed an up-regulation of cancer-related pathways, such as epithelial mesenchymal translation (EMT) and KRAS signaling (Normalized Enrichment Score (NES) intensity: 1.51 and 1.73, respectively) reflecting the aggressiveness of AYA-RMS. The gene discussed is KRAS; the disease is cancer.