In order to explore the underlying mechanism of VAC in regulating the endothelium-dependent vasodilation dysfunction, subsequently, in this study, through in vitro intervention of HMEC-1 endothelial dysfunction model induced by HG, it was proved that VAC could inhibit vascular endothelial dysfunction through the ROS/AMPK/miRNA-34a/eNOS signaling pathway (Figure 7). Here, NOS3 is linked to endothelial dysfunction.