B. intestinihominis, which is accumulated in the colon, improves systemic amount of Th1 and Tc1, polyfunctional CD8+ cytotoxic T-cells subpopulation, associated with an increase of IFN-y-producing γδ tumor infiltrating-lymphocytes (TILs) which could also increase the anti-tumor effect of CTX (Figure 1) [11,32,35]. This evidence concerns the gene CD8A and neoplasm.