SREBF1 and malignant colon neoplasm: MYC has been shown to cooperate with sterol regulatory element-binding protein 1 (SREBP1), a transcription factor involved in regulating lipid homeostasis that was shown to promote epithelial-mesenchymal transition in colon cancers [27] and ER regulates expression of at least 20 genes involved in fatty acid metabolism in breast cancer [28].