RHO and infection: Perhaps reflective of the different context of activation, and consistent with the rapid MAIT cell expansion observed with infection in vivo (Meierovics et al., 2013, Wang et al., 2018), the murine MAIT cells activated by the acute L. longbeachae infection showed a very strong activation of cell cycle pathways, as well as signaling by RHO guanosine triphosphatases (GTPases) and chemokine receptor-ligation, with similar dominance of the cell cycle when MAIT cells activated by acute infection were contrasted directly with unstimulated MAIT cells after infection resolution (Figures 2C and 2D).