To answer these questions, we identified direct cis-element interactions using the Promoter Capture Hi-C (CHi-C) method (Mifsud et al., 2015) in Kasumi-1 cells, a well-known model of t(8;21) AML, with and without small interfering RNA (siRNA)-mediated RUNX1-ETO depletion. The gene discussed is RUNX1; the disease is acute myeloid leukemia.