Furthermore, the higher expression of PADI3 in TN-IBC SUM149 cells than in TN-non-IBC MDA-MB-231 cells (Fig 3A) and the finding depletion of PADI3 reduced the proliferation of SUM149 cells (Fig 3B) indicated that PADI3 may play an important role in promoting the aggressiveness of IBC. Here, PADI3 is linked to inflammatory breast carcinoma.