Furthermore, MEF2a, MEF2c, and MEF2d are well characterized for their crucial roles in cardiac hypertrophy (van Oort et al, 2006; Xu et al, 2006; Kim et al, 2008; Gao et al, 2016), and MEF2b has been implicated to play a role in cardiac development (Molkentin et al, 1996). This evidence concerns the gene MEF2D and cardiac hypertrophy.