CREM and cardiac hypertrophy: Similarly, other regulators such as NGF1A‐binding protein, inducible cAMP early repressor, and interferon regulatory factor 9 play inhibitory roles in cardiac hypertrophy, and the expression of these molecules all increases in response to hypertrophic stimuli (Tomita et al, 2003; Hardt & Sadoshima, 2004; Buitrago et al, 2005; Jiang et al, 2014; Guo et al, 2018).