Notably, amiloride alleviated the augmented cytokine secretion, as well as caspase-1 activity in both primary CF monocytes (IL-18 p=0.0001; IL-1β p=0.0272) and HBEC lines (Figure 5A,B,E) (Montgomery et al., 2017; Fritzsching et al., 2015; Mall et al., 2004). The gene discussed is IL18; the disease is cystic fibrosis.