EPAS1 and nutritional disorder: Like mammals, intestinal iron absorption in C. elegans is upregulated during iron deficiency by HIF-transcriptional activation of smf-3/DMT1 (C. elegans, HIF-1; human, HIF-2α, EPAS1) (Mastrogiannaki et al., 2009; Romney et al., 2008; Shah et al., 2009).