Nevertheless, even if tumor-derived fragments are captured by neighboring DEC-205+ DCs that possess cross-presentation, and those tolerogenic DCs expressed processed tumor epitope(s) associated with class I MHCs with insufficient co-stimulatory molecules, tumor-specific CD8+ CTLs are unable to be primed from naïve CD3+ T cells in an MHC-restricted manner. The gene discussed is HLA-C; the disease is neoplasm.