PLD1 and neurodegenerative disease: Phospholipase D1 (Pld1), Phospholipase D2 (Pld2) and Pten were 4–6-fold upregulated in surviving host at 28 DPI, and have been implicated in neurodegenerative diseases and downstream signaling of ß-amyloid and amyloid precursor protein (APP) (Supplementary Fig. 4A).33,34 The PD array revealed sixfold upregulation of Immune-related GTPase M (Irgm1), which is associated with neuronal autophagy (Supplementary Fig. 4C).35DJ-1 protein (Park7) was upregulated fourfold in surviving host mice as well.