Several years ago, a case of systemic amyloidosis of two separate proteins (transthyretin and ApoAIV) with distinct deposition patterns was described, and recently, in our university, ApoAIV type of systemic amyloidosis was discovered in a PACAP-KO mice strain, which all may indicate the primary amyloidogenic potential of the ApoAIV protein [31, 32]. This evidence concerns the gene TTR and primary systemic amyloidosis.