Considering the importance of FMF and its significant prevalence in the northwest of Iran, near Mediterranean region [1], and the significant role of MEFV gene in many rheumatologic diseases such as Behcet's disease, PAN, HSP, and even nonrheumatologic disorders [3], it is necessary to identify different variations of this mutations in the unaffected and normal population of this area, which is near to Mediterranean Sea. Here, MEFV is linked to familial Mediterranean fever.