The potentiation produced by TRPA1 activation on impaired EFS contraction in the OZR bladder suggests that, in addition to increased TRPA1 receptor expression, an augmented functionality of TRPA1 receptors, located at CSPA, in the impaired excitatory neurotransmission from the OZR bladder seems to be involved in obesity-related micturition disorder. Here, TRPA1 is linked to obesity due to melanocortin 4 receptor deficiency.