CASP1 and colitis: In 2010, the study by Zaki et al. [23] showed that the susceptibility to colitis induced by oral 3% DSS and TNBS enema was clearly increased in NLRP3-, ASC-, and caspase-1-deficient mice, which suggested that the NLRP3 inflammasome was extremely critical to the maintenance of the intestinal homeostasis.