The introduction of ginger causes the dissociation of Nrf2 from Keap1 in the cytosol, and Nrf2 subsequently translocates into the nucleus, where Nrf2 binds to antioxidant response element (ARE) and initiates the transcription of antioxidant genes such as thioredoxin 1, thioredoxin reductase 1, and heme oxygenase-1, which could result in a protective effect on ageing and degenerative diseases [91]. The gene discussed is NFE2L2; the disease is neurodegenerative disease.