There has been one study from Mashhad (Iran) on the Immunohistochemical expression of EGFR in lung cancer (7), however, to the best of our knowledge there has been no report on the EGFR mutation’s molecular analysis and incidence in lung adenocarcinoma from Iran, so in this study we attempt to evaluate the prevalence of these muta- tions in our center, the largest referral center in the south of Iran. The gene discussed is EGFR; the disease is lung adenocarcinoma.