In 2012, Kovesdi et al. shown that Acute minocycline treatment in 4 consecutive days resulted a significant reduction in serum levels of all neuronal and damage markers like NSE, NF-H, Tau, S100B except for Glial fibrillary acidic protein (GFAP) in a rat model of mild blast traumatic brain injury. This evidence concerns the gene S100B and brain injury.