Increasing in serum creatinine is relatively slow, and it takes at least 48 to reach a level of nephropathy; however, using biomarker of kidney function that are more rapidly rising and are the precise and sooner markers, which better indicate to nephropathy such as cystatin C, allow more accurate estimation of CIN (29). This evidence concerns the gene CST3 and cervical squamous intraepithelial neoplasia.