TP53 and cancer: The apoptotic effects of high doses of noscapine were investigated in cancer cell lines, including human and animals, but anti-cancer effect of noscapine was not determined completely; however, it seems that this activity is mediated by several mechanisms, such as induction of apoptosis (14, 26), expression of P53 and P21, as well as suppression of BCL-2 and antitubuline properties (12, 27).