In fact, it has been shown that purinergic receptors (P2X7R) silencing reduces radiotherapy-induced GBM cell cytotoxicity in addition to a less-efficient radiotherapy-induced cell death, demonstrating that high P2X7 expression levels and function are a good prognostic factor for GBM radiosensitivity [34, 35]. This evidence concerns the gene P2RX7 and glioblastoma.