Specifically, the authors found that EMT is highly associated with an inflammatory tumor microenvironment, increased expression of multiple immune checkpoint molecules (e.g., PD-L1, PD-L2 PD-1, T-cell immunoglobulin and mucin domain 3 (TIM-3), B- and T-lymphocyte attenuator (BTLA), and cytotoxic T-lymphocyte antigen 4 (CTLA-4)), and a high number of infiltrating Tregs. Here, CD274 is linked to neoplasm.