We found the mRNA level of JUN, TLR4, VEGFA, and TNFSF10 in the PBMC of HCC patients was significantly upregulated in the PBMC of HCC patients (P < 0.05), of which VEGFA increased obviously (P < 0.01) (Figures 4(a)–4(d)). Here, TLR4 is linked to hepatocellular carcinoma.